This randomized, double-blinded and placebo-controlled trial has evaluated the effects of green cardamom (3 g/day for 10 weeks) in 83 overweight or obese type 2 diabetic patients. The authors examined the effects of the supplementation in anthropometric parameters, glycemic indices and blood lipids. Serum sirtuin-1 level has also been assessed.

In comparison to the placebo, green cardamom has reduced plasma HbA1c (-0.4%), insulin (-2.8 µIU/dL) and triglycerides (-39.9 mg/dL). Moreover, an improvement in insulin sensitivity has been noted, highlighted by the reduction in the HOMA-IR indice (-1.7). Finally, an increase in sirtuin-1 level has been measured.

The authors concluded that green cardamom may improve some metabolic parameters in overweight or obese type 2 diabetic patients by increasing the Sirtuin-1 level.

Aghasi M, Koohdani F, Qorbani M, Nasli-Esfahani E, Ghazi-Zahedi S, Khoshamal H, Keshavarz A, Sotoudeh G. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agric. 2019 Jan 30.