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A garlic extract reduces blood pressure in hypercholesterolaemic subjects

This randomized, double-blinded, placebo-controlled and crossover study investigated the effects of an optimized aged garlic extract on cardiovascular risk factors in moderate hypercholesterolemic subjects. 67 subjects received a placebo or 250 mg/day of garlic extract (1.25 mg S-allyl-L-cysteine) for 6 weeks.

The extract induced a reduction in diastolic blood pressure (mean reduction: -5.85 mmHg, 95% CI -105, -1.3 mmHg) compared to placebo, particularly in men with diastolic blood pressure over 75 mmHg. No other cardiovascular risk factors have been affected.

Therefore, an aged garlic extract seems to be able to reduce blood pressure in subjects with moderate hypercholesterolemia.

Valls RM, Companys J, Calderón-Pérez L, Salamanca P, Pla-Pagà L, Sandoval-Ramírez BA, Bueno A, Puzo J, Crescenti A, Bas JMD, Caimari A, Salamanca A, Espinel AE, Pedret A, Arola L, Solà R. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustained and Controlled Study. Nutrients. 2022 Jan 18;14(3):405.