This meta-analysis examined the effects of orange juice on cardiovascular risk factors. The aim of the authors was to assess the effects of orange juice on major cardiometabolic markers, including anthropometric indices, blood pressure, lipid profile, inflammation, and glycemic control markers. 15 trials have been included in the analysis, for a total of 639 participants.

Results showed that orange juice intake was associated with a reduction in total cholesterol (WMD = -6.84 mg/dL, 95% CI: -12.38 to -1.29, p = 0.01) and homeostatic model assessment for insulin resistance (WMD = -0.39, 95% CI: -0.77 to -0.006, p = 0.04). All other markers were not affected by orange juice.

Therefore, this meta-analysis suggests that orange juice may reduce blood cholesterol and improve insulin sensitivity.

Motallaei M, Ramezani-Jolfaie N, Mohammadi M, Shams-Rad S, Jahanlou AS, Salehi-Abargouei A. Effects of orange juice intake on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2021 May 31.

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